Studies on glucosaminidase; N-acetyl-beta-glucosaminidase in rat kidney.
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چکیده
منابع مشابه
Increase of lead-induced release of N-acetyl-p-D-glucosaminidase by NO synthase in perfused kidney of rat
Urinary N-acetyl-β-D-glucosalninidase (NAG) has been proved to be a useful marker of early renal injury as a result of factors such as lead toxicity. In this study the effect of lead acetate on the kidney and its correlation with the nitric oxide (NO) system was investigated by determining the NAG release in perfused kidney of rat. Lead acetate caused a time- and dose-dependent increase in en...
متن کاملExcretion of urinary N-acetyl-beta-D-glucosaminidase isoenzymes after renal transplantation in the rat.
The urinary excretion of N-acetyl-beta-D-glucosaminidase isoenzymes A and B following kidney transplantation was studied in rats. High enzymuria with permanent marked isoenzyme B excretion occurred from the immediate post-operative period to the irreversible rejection episode. Isoenzyme B could represent as much as 10-40% of total N-acetyl-beta-D-glucosaminidase activity and it reflected the in...
متن کاملIs urinary N-acetyl-beta-D-glucosaminidase a marker of urological abnormality in children?
Abstract Background: Hydronephrosis is the most common congenital condition that is detected by prenatal ultrasonography. Moreover, the widespread use of prenatal ultrasonography results in an increased recognition of fetal hydronephrosis. Prenatal hydronephrosis is diagnosed at an incidence of 1:100 to 1:500 by ultrasonographic studies. The presence of hydronephrosis is not synonymou...
متن کاملThe clinical value of urinary N-acetyl-beta-D-glucosaminidase levels in childhood age group.
N-acetyl-beta-D-glucosaminidase is a high molecular-weight lysosomal enzyme found in many tissues of the body. It cannot pass into glomerular ultrafiltrate due to its high molecular weight. However, this enzyme shows high activity in renal proximal tubular cells, and leaks into the tubular fluid as the ultrafiltrate passes through proximal tubules. When proximal tubular cells are injured due to...
متن کاملLysosomal N-acetyl-beta-D-glucosaminidase: interneuronal differences in activity and molecular forms.
The lysosomal N-acetyl-fl-D-glucosaminidase (EC 3.2.1.30) of brain tissue 1~ has been extensively studied in our laboratory 7,15-1s, with particular emphasis on the distinction between its neuronal and glialT,10,19 components. Evidence for two neuron-al components in the immature rat cerebral cortex, each with distinct characteristics, was presented in 1973 (ref. 18). More recently, we demonstr...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 65 3 شماره
صفحات -
تاریخ انتشار 1957